Jackson Lumen Christi and Jackson United hockey teams join together for Hockey Fights Cancer

, December 20, 2012 8:30 a.m.

These wrist bands will be sold for $3 each during the Hockey Fights Cancer event in an effort to raise funds for the fight against cancer. - (MLive Media)

JACKSON, MI ? When Marko Gleeson takes the ice Saturday, the Lumen Christi High School senior will be playing for more than most on that night.

Gleeson?s father, Michael, a sergeant with the Jackson County Sheriff?s Office, died Oct. 3 after a battle with lung cancer.

In honor of his father ? and others who have lost or are in a battle with cancer ? Gleeson and his Lumen Christi teammates and their chief rivals, Jackson United, are banding together for an event to raise funds for Relay for Life.

Hockey Fights Cancer will take place Saturday at Optimist Ice Arena featuring games between Jackson United and Ann Arbor Gabriel Richard at 5:30 p.m. and Lumen Christi and Dexter at 8 p.m.

Losing his father was difficult, especially since Gleeson?s grandmother died earlier this year.

?Through that, I learned that everyone has to go at some point, and it was his time,? Gleeson said.

His father played a large role in Gleeson?s life and athletic career. Gleeson said his father used to take him fishing and play basketball with him, but his best memories were of the long trips he and his father shared when he was a young member of the Jackson Generals hockey program.

?We really connected with all the travel to away games,? he said. ?I can remember we had a van and he?d dress me in the van when I was little and we were running late.?

On Saturday, prior to the first game, all the captains from the Jackson United, Lumen Christi and Gabriel Richard teams will join together at center ice for a ceremonial dropping of the puck. Pucks will also be presented to Marko Gleeson as well as Michael Gleeson?s parents, Susan and Roger.

Admission costs $1 admission for students and $5 for adults with discounts for large groups. All te funds raised during the event will be donated to Relay for Life.

?We just want everyone to enjoy high school hockey while raising awareness for a great cause,? Jackson United coach Eric Morgan said. ?I think it?s definitely going to be a sight to see this year.?

Marko Gleeson said wrist bands have been ordered for the games and will be sold for $3 each in an effort to raise funds for the fight against cancer. The wrist bands ? which are black with hot pink lettering that reads ?Hockey Fights Cancer Jackson United * LCHS? ? will be available for purchase at the games.

?I?m just really honored to be a part of this,? Gleeson said.

IN CASE YOU GO?

What: Hockey Fights Cancer

Where: Optimist Arena

When: 5 p.m., Saturday, Dec. 22

Who: Jackson United vs. Gabriel Richard, 5:30 p.m.; Jackson Lumen Christi vs. Dexter, 8 p.m.

Admission: $1 for students; $5 for adults; discounts for groups

Source: http://highschoolsports.mlive.com/news/article/6297230902664781481/jackson-lumen-christi-and-jackson-united-hockey-teams-join-together-for-hockey-fights-cancer/

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Sprint improves Chicago LTE coverage, brings 4G to a few other new areas

DNA Sprint expands LTE coverage in Chicago, while adding six new territories to its 4G reach

Today, Sprint expanded its existing LTE coverage for customers in the Chicago metropolitan area. Not stopping at the Windy City, the carrier dropped six more regions into its high-speed bucket: Indianapolis, Indiana; York and Franklin County Pennsylvania; Santa Rosa California, Vallejo, California; Shenandoah County, Virginia and Southern Puerto Rico. These may not be the highly populated areas that some people are craving, but be mindful that some big city folks have encountered phantom 4G with a promise of the real thing coming soon. As Sprint moves forward with its network development plans, hopefully you won't have to wait too much longer before the LTE train makes a stop in your neighborhood.

Continue reading Sprint improves Chicago LTE coverage, brings 4G to a few other new areas

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/FoR8P5W5GH4/

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5 Ways To keep a Happy Husband - Relationship Advice - Giving ...

Marriage is a full time job and keeping a husband satisfied, content and not a cheating partner can take time and effort. Having said that, here are just five simple ways to make a start;

1. It?s Good to Talk. A couple that can easily communicate and feel secure in the knowledge that they seem interesting no matter what the subject is usually a happy one. It was probably what brought them together in the first place. When he talks, listen to him no matter how bored you are! To share a story or experience and laugh together is a great feeling and one that should be kept alive. How often do you see couples sitting in silence in a restaurant? How often have you looked at them and thought thank heavens that?s not me! Well, it doesn?t have to be you. Just make sure you find new subjects or find new experiences to keep your time together interesting.

2. Spontaneity. What started out as that very exciting time when you were dating has, as in most relationships, been replaced by familiarity and routine and that same daily routine can become boring. Spontaneity is what is needed. To keep infidelity at bay arrange to spend some quality time together. A weekend away or a romantic dinner, be it in a restaurant or at home. Something to look forward to is a great feeling.

3. Appreciation. Men like to be appreciated. It is a rare occasion when a man will make a selfless gesture and expect nothing in return. It can work in your favor to thank him for even the smallest of those gestures. If he cooks the dinner or washes the dishes make sure you tell him how happy you are. Treat him with respect and appreciate the time that you do get to spend together. Tell him how much you love him. People never get tired of hearing how much they are loved.

4. Night Night. If at all possible always go to bed at the same time. That last kiss and cuddle is very important and can leave you feeling loved and contented and then there is of course that age old warning! Never go to sleep on an argument. Equally important is to never get boring in bed. That is a sure way to send your husband into the arms of a more eager companion! If you are happy and that spark is still there then keep it alive. Try new positions, new times, new places but most of all don?t give up. In time the lust will be replaced by something much deeper but until that time, there?s no harm in trying all things new!

5. Can?t be Bothered It was probably love at first sight when your husband first saw you. The way you dressed or wore your make up were big factors on how attractive he found you. A big problem in married life then can be the ability to let this slip Comfort replaces the need to appeal. Dress down day is fine so long as it does not become the norm. If you can?t be bothered then why should he. Don?t lose him to a younger version of you, show him why he is with you by keeping some of the things the first attracted him about you the same and he will not be tempted to commit adultery,.

Of course, if any of these situations are proving more difficult than normal to achieve that level of happiness, then maybe there is an underlying problem.

If you suspect your partner of cheating call Private Detective In UK we will help you find the truth and stop the sleepless nights http://www.theprivatedetective.com

Source: http://www.couplesadvice.com/5-ways-to-keep-a-happy-husband/

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.CO in the 2013 Super Bowl ? Joins Go Daddy Again! | TNTNames ...

Inspiring Entrepreneurship & SMB Creation on the World?s Largest Stage

Scottsdale, AZ (PRWEB) December 19, 2012

For the third year in a row, Go Daddy is teaming up with the .CO domain to create a 2013 Super Bowl commercial aimed at anyone who has ever thought about starting their own business. The 30-second ad is set to feature Go Daddy Girl Danica Patrick, but that?s about all either company is revealing about the commercial at this point.

.CO is one of the fastest-growing domain name extensions on the Internet and is a commonly referenced abbreviation for ?company.? Like Go Daddy, .CO is intently focused on helping small businesses, innovators and entrepreneurs to achieve their dreams online.

?It?s a fun story to tell, the trick is to do it in thirty seconds,? said Juan Diego Calle, CEO and Founder of .CO Internet S.A.S., the company behind the .CO domain. ?The Super Bowl is unlike any other broadcast event in the world. We get to share our message with more than a hundred million people during a program where many tune in especially for the commercials. So what will we do? We?re going to inspire people to seize the moment ? to actually launch their big ideas online!?

Go Daddy, the world?s leading Web hosting and domain name provider, has certainly delivered historically when it comes to Super Bowl campaigns. Go Daddy?s Super Bowl resume includes records for Share of Voice, highly sought-after in the PR battles, and Internet traffic spikes, a bonanza for any business.

?Partnering with the dot-CO domain is a great fit for Go Daddy, especially considering we share the same goal of helping small businesses leverage the power of the Internet,? said Go Daddy CMO Barb Rechterman. ?Domain names and websites are part of the mainstream vernacular now and there?s no better place to tell a story than in a Super Bowl commercial.?

The story-telling for the 2013 .CO ad will revolve around how easy it is to create your own business online and use the Internet to grow it quickly. The commercial is being shot in Los Angeles in early January and was developed by the Deutsch NY team.

The Go Daddy, .CO partnership has proven successful in two previous years. Last year?s ?Body Paint? Super Bowl ad drove significant traffic to the GoDaddy.co website. In 2011, .CO garnered massive attention as iconic comedienne Joan Rivers was revealed as the ?surprise? new Go Daddy .CO Girl. That commercial triggered a record-breaking 466 percent increase in domain name registrations within 15 minutes of airing.

One company that experienced the power of registering a .CO domain on the heels of the first .CO Super Bowl ad is CauseForCelebration.CO, an event planning business with a cause-supporting twist. ?The introduction of .CO was a milestone in my business,? said company owner and Go Daddy customer Janet Finden. ?The availability of dot-CO allowed me to secure an ideal domain name to deliver my brand message online.?

To register your .CO domain name, visit GoDaddy.CO.

To find out more about starting a business online, visit Go Daddy.

About Go Daddy

Go Daddy is the world?s largest domain name provider, Web hosting provider and new SSL certificate provider, focused on helping small businesses grow larger. Go Daddy provides dozens of cloud-based services and is the largest worldwide mass-market hosting provider by annual revenue according to Tier1 Research (Mass-Market Hosting Report-Winter 2011) and is the #1 provider of net-new SSL certificates for 2011, according to the Netcraft, LTD Secure Server Survey. To learn more about the company, visit GoDaddy.com/PR.

About .CO

In just over two years since its launch, the .CO domain has become one of the most successful top level domain extensions in history, with nearly 1.4 million web addresses registered by people and companies in over 200 countries. From start-ups and small businesses to big brands and multinational corporations, .CO is increasingly becoming the web address of choice for innovators and entrepreneurs the world over. For more information about .CO, please visit go.co or follow us on Twitter @dotCO.

Source: http://www.tntnames.com/blog/co-in-the-2013-super-bowl-joins-go-daddy-again.html

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Changing our material future, layer by layer

[ Back to EurekAlert! ] Public release date: 20-Dec-2012
[ | E-mail | Share Share ]

Contact: Daniel Cochlin
daniel.cochlin@manchester.ac.uk
0044-161-275-8387
University of Manchester

The proposal, which will involve researchers from the Universities of Manchester, Cambridge and Lancaster, has been awarded 13.4 million Euros (around 11m) to form a "Synergy Group" by the European Research Council (ERC).

It will aim to utilise two-dimensional substances, such as wonder material graphene, to engineer new types of materials which are just a few atoms thick, but nevertheless have the power to revolutionise the future development of devices such as solar cells, and flexible and transparent electronics.

Starting with one atom-thick substances which possess remarkable properties, the group will focus on ways in which they can be layered up to form 'heterostructures'. These heterostructures will still be just a few atoms thick, but will combine the properties of the different two-dimensional materials which comprise them, effectively enabling developers to embed the functions of a device into its very fabric.

For example, the research team envisage combining an atomic layer which functions as a sensor, with layers that function variously as an amplifier, transistor, or solar cell, for power generation. The resulting material, still just a few atomic layers in thickness, would be capable of running a whole circuit.

The award to launch the project was announced by the ERC as part of its first competition for 'Synergy Grants', which were introduced last year on a pilot basis. It will bring together the talents of the Nobel Prize-winner, Professor Kostya Novoselov at Manchester, Professor Andrea Ferrari at Cambridge, and Professor Vladimir Falko at Lancaster.

The team will be part of the UK's Graphene Global Research and Technology Hub, including the 61m National Graphene Institute, which is being developed at The University of Manchester to continue its world-leading and collaborative work in the field.

Widely regarded as a wonder material on account of its numerous capabilities, graphene is a two-dimensional structure consisting of a single layer of carbon atoms arranged in a honeycomb or chicken wire structure. It was first isolated by Professor Andre Geim and Professor Kostya Novoselov at The University of Manchester in 2004.

It is the thinnest material in the world and yet also one of the strongest. It conducts electricity as efficiently as copper and outperforms all other materials as a conductor of heat.

The Synergy Group will aim to combine these properties with those of other, two-dimensional materials for the sake of creating an amazing range of applications and devices, among them new types of transistors, solar cells and other optoelectronic components.

Professor Novosleov said: "The award of the Synergy Grant is an exciting development. We bet on the high-risk idea that by combining the properties of several, one-atom thick materials into a single, three-dimensional heterostructure, we would create a new class of materials with predetermined properties and multiple functionalities."

"You might think that building materials layer by layer is science fiction. But if we succeed, this new combination of known materials, the two-dimensional atomic crystals, built layer by layer, will offer an amazing range of applications and devices."

Professor Ferrari said: "The impact of the proposed research can be imagined considering that graphene is just one of a potentially endless range of embodiments of the general concept we aim to explore in this project. This new field of research will open new horizons and opportunities for science, technology and scholarship."

"The combined expertise in physics, engineering and theoretical modelling combing from the synergy of our three groups and institutions will be key to achieving our objectives."

Professor Falko said: "Our project is challenging, both at the technical and conceptual level. We aim to extend science and technology of atomically thin films into materials far beyond graphene, where properties of atomically thin crystals are not known, yet."

"This project offers excellent opportunities for the early career researchers, who, thanks to the ERC, will be able to join our team theorists, experimentalist and engineers - to enjoy surprises and make discoveries."

In total, 11 projects from more than 700 original applications were selected to receive ERC funding.

The President of the ERC, Professor Helga Nowotny, said: "The ERC Synergy Grant provides a unique opportunity for outstanding scientists to explore jointly-formulated research questions, which take them beyond normal even if otherwise excellent science."

"It aims to bring together the right kind of people at the right time, in the right configuration, to work on the right kind of problem. This grant scheme gives researchers a lot of freedom to work together in new ways."

###



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


[ Back to EurekAlert! ] Public release date: 20-Dec-2012
[ | E-mail | Share Share ]

Contact: Daniel Cochlin
daniel.cochlin@manchester.ac.uk
0044-161-275-8387
University of Manchester

The proposal, which will involve researchers from the Universities of Manchester, Cambridge and Lancaster, has been awarded 13.4 million Euros (around 11m) to form a "Synergy Group" by the European Research Council (ERC).

It will aim to utilise two-dimensional substances, such as wonder material graphene, to engineer new types of materials which are just a few atoms thick, but nevertheless have the power to revolutionise the future development of devices such as solar cells, and flexible and transparent electronics.

Starting with one atom-thick substances which possess remarkable properties, the group will focus on ways in which they can be layered up to form 'heterostructures'. These heterostructures will still be just a few atoms thick, but will combine the properties of the different two-dimensional materials which comprise them, effectively enabling developers to embed the functions of a device into its very fabric.

For example, the research team envisage combining an atomic layer which functions as a sensor, with layers that function variously as an amplifier, transistor, or solar cell, for power generation. The resulting material, still just a few atomic layers in thickness, would be capable of running a whole circuit.

The award to launch the project was announced by the ERC as part of its first competition for 'Synergy Grants', which were introduced last year on a pilot basis. It will bring together the talents of the Nobel Prize-winner, Professor Kostya Novoselov at Manchester, Professor Andrea Ferrari at Cambridge, and Professor Vladimir Falko at Lancaster.

The team will be part of the UK's Graphene Global Research and Technology Hub, including the 61m National Graphene Institute, which is being developed at The University of Manchester to continue its world-leading and collaborative work in the field.

Widely regarded as a wonder material on account of its numerous capabilities, graphene is a two-dimensional structure consisting of a single layer of carbon atoms arranged in a honeycomb or chicken wire structure. It was first isolated by Professor Andre Geim and Professor Kostya Novoselov at The University of Manchester in 2004.

It is the thinnest material in the world and yet also one of the strongest. It conducts electricity as efficiently as copper and outperforms all other materials as a conductor of heat.

The Synergy Group will aim to combine these properties with those of other, two-dimensional materials for the sake of creating an amazing range of applications and devices, among them new types of transistors, solar cells and other optoelectronic components.

Professor Novosleov said: "The award of the Synergy Grant is an exciting development. We bet on the high-risk idea that by combining the properties of several, one-atom thick materials into a single, three-dimensional heterostructure, we would create a new class of materials with predetermined properties and multiple functionalities."

"You might think that building materials layer by layer is science fiction. But if we succeed, this new combination of known materials, the two-dimensional atomic crystals, built layer by layer, will offer an amazing range of applications and devices."

Professor Ferrari said: "The impact of the proposed research can be imagined considering that graphene is just one of a potentially endless range of embodiments of the general concept we aim to explore in this project. This new field of research will open new horizons and opportunities for science, technology and scholarship."

"The combined expertise in physics, engineering and theoretical modelling combing from the synergy of our three groups and institutions will be key to achieving our objectives."

Professor Falko said: "Our project is challenging, both at the technical and conceptual level. We aim to extend science and technology of atomically thin films into materials far beyond graphene, where properties of atomically thin crystals are not known, yet."

"This project offers excellent opportunities for the early career researchers, who, thanks to the ERC, will be able to join our team theorists, experimentalist and engineers - to enjoy surprises and make discoveries."

In total, 11 projects from more than 700 original applications were selected to receive ERC funding.

The President of the ERC, Professor Helga Nowotny, said: "The ERC Synergy Grant provides a unique opportunity for outstanding scientists to explore jointly-formulated research questions, which take them beyond normal even if otherwise excellent science."

"It aims to bring together the right kind of people at the right time, in the right configuration, to work on the right kind of problem. This grant scheme gives researchers a lot of freedom to work together in new ways."

###



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?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-12/uom-com122012.php

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House pushes to complete $633 billion defense bill

(AP) ? The House pushed to complete a $633 billion defense bill for next year despite Pentagon complaints that it spares outdated but politically popular weapons at the expense of the military's ability to fight.

Lawmakers were expected to vote Thursday evening and send the legislation to the Senate, where leaders hoped to wrap up the measure for President Barack Obama's signature.

The far-reaching policy bill that covers the cost of ships, aircraft, weapons and military personnel would authorize $528 billion for the Defense Department's base budget, $17 billion for defense and nuclear programs in the Energy Department and $88.5 billion for the war in Afghanistan.

The bill is $1.7 billion more than Obama requested.

House Republicans and Democrats debated the measure against the backdrop of high-stakes talks to avert the so-called fiscal cliff of automatic tax hikes and spending cuts and the loud cry for a sweeping deal to slash the deficit.

Democrats argued that the bill runs counter to demands for fiscal discipline.

"This bill is more money that the Pentagon wants," said Rep. Jim McGovern, D-Mass. "We're just throwing money at them."

Specifically, the bill spares a version of the Global Hawk unmanned aircraft, includes upgrades for tanks and money for armored vehicles.

In a speech this week, Defense Secretary Leon Panetta criticized the pressure on the Pentagon to keep weapons that it doesn't want. "Aircraft, ships, tanks, bases, even those that have outlived their usefulness, have a natural political constituency. Readiness does not," Panetta said.

"What's more, readiness is too often sacrificed in favor of a larger and less effective force. I am determined to avoid that outcome," he said.

Panetta said members of the House and Senate "diverted about $74 billion of what we asked for in savings in our proposed budget to the Congress, and they diverted them to other areas that, frankly, we don't need."

The bill responds to the new threats and upheaval around the globe while still providing billions for the decade-plus war in Afghanistan. The measure would tighten sanctions on Iran, increase security at diplomatic missions worldwide after the deadly Sept. 11 raid in Libya and presses the military on possible options to end the bloodshed in Syria.

Election-year politics and changes in society shaped the final measure. Negotiators kept a Senate-passed provision sponsored by Sen. Jeanne Shaheen, D-N.H., that expands health insurance coverage for military women and their dependents who decide to have abortions in cases of rape and incest.

Previously, health coverage applied only to abortions in cases where the life of the mother was endangered.

Democrats argued throughout the election year that Republicans were waging a "war on women" over contraception and abortion, a charge the GOP denied. Democrats and President Barack Obama held a clear edge with female voters, which led to soul-searching within the GOP.

Negotiators jettisoned a House provision that would have banned gay marriage on military installations, weeks after the chapel at the U.S. Military Academy at West Point held its first same-sex marriage. A senior Army chaplain conducted the ceremony. The bill does include a conscience clause for chaplains.

The measure includes a 1.7 percent pay raise for military personnel and provides money for new ships, aircraft and other weapons.

The sanctions would hit Iran's energy, shipping and shipbuilding sectors as well as Iran's ports, blacklisting them as "entities of proliferation concern." It would impose penalties on anyone supplying precious metals to Iran and sanctions on Iranian broadcasting.

The bill eliminated a House provision barring the military from buying alternative fuels if the cost exceeds traditional fossil fuels, a measure that had drawn a veto threat. Instead, negotiators said the Pentagon could move ahead on the project as long as the Energy and Agriculture departments make their financial contributions to the work.

The bill also watered down a House effort to require construction of an East Coast missile defense site, instead pressing the Pentagon to study three possible locations.

Months after the attack on the U.S. consulate in Benghazi, Libya, that killed Ambassador Chris Stevens and three other Americans, the bill would provide an additional 1,000 Marines for embassy security.

Reacting to relentless violence in Syria, the bill would require the Pentagon to report to Congress on possible military options.

The bill would authorize nearly $480 million for the U.S.-Israeli missile defense, including $211 million for Iron Dome, the system designed to intercept short-range rockets and mortars fired by Palestinian militants from Gaza at southern Israel.

One of the thorniest issues in negotiations was the handling of terrorist suspects. Lawmakers finally agreed on language that says "nothing in the authorization for the Use of Military Force or (the current defense bill) shall be construed to deny the availability of the writ of habeas corpus or to deny any constitutional rights" to an individual in the United States who would be entitled to such rights.

The agreement retained a Senate provision that stops the Pentagon from sending additional spies overseas until Congress has answers about the cost and how the spies would be used.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-12-20-Defense%20Bill/id-46b77715e7fa475fb2097d4a8059ab84

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Cop suspended amid roadside cavity search claims

By Frank Heinz and Ken Kalthoff, NBCDFW.com

A Texas state trooper has been suspended with pay, officials said Wednesday, after two women claimed they were subjected to intimate body cavity searches at the roadside in full view of the public.

The two women, from Irving, Texas, are suing two state troopers and the director of the Department of Public Safety, alleging they were violated during what they call an unconstitutional search on State Highway 161 on July 13.

Angel Dobbs and her niece Ashley Dobbs were stopped for littering by Trooper David Farrell.

In a dashcam video released by the women and their attorney, Farrell can be heard telling the women they would both be cited for throwing cigarette butts out of the car.

Farrell called for a female trooper, Kelley Helleson, to come to the scene and began to ask questions about what he described as ?an odor of marijuana? coming from the car, according to the video. Angel Dobbs denied smoking marijuana, and said she had borrowed the car.

'Humiliated'
After Helleson arrived, she can be seen in the video putting on blue latex gloves to conduct a search of both women. According to the lawsuit, when Angel Dobbs asked about the gloves, Helleson "told her not to worry about that."

Pulled over for littering, women given body cavity searches

In the lawsuit, Dobbs said the trooper conducted the cavity search on the roadside, illuminated by the police car's headlights, in full view of any passing motorists.

"This has been an eye-opening experience for me. I've never been pulled over, never searched like this. I was totally violated over there a few minutes ago... this is so embarrassing to me," Angel Dobbs said on the video.

"I've never been so humiliated or so violated or felt so molested in my entire life," Angel Dobbs told NBCDFW.com.

More stories from NBCDFW.com

The lawsuit further alleges that Helleson performed the searches on both women without changing the latex gloves between searches.

"I don't think anybody needs to have to feel, or go through what we went through," Ashley Dobbs said. "It crosses my mind every day. It's humiliating," she said.

The Department of Public Safety told NBCDFW.com that Helleson had been suspended with pay.

There had been no other suspensions as of Wednesday night, NBCDFW.com reported.

No narcotics or contraband was found, according to the lawsuit.

Source: http://usnews.nbcnews.com/_news/2012/12/20/16036233-trooper-suspended-after-women-sue-over-roadside-cavity-searches?lite

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Described a key mechanism in muscle regeneration

[ Back to EurekAlert! ] Public release date: 19-Dec-2012
[ | E-mail | Share Share ]

Contact: Ral Toran
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute

The association alfa-enolase/plasmin is a new selectively target for treating muscular pathologies

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) have described a new selective target in muscle regeneration. This is the association of alpha-enolase protein and plasmin. The finding could be used to develop new treatments to regenerate muscular injuries or dystrophies. The study has been published in PLOS ONE journal.

Skeletal muscle has a great regeneration capacity after injury or genetic diseases such as Duchenne muscular dystrophy, the most common neuromuscular disorder in children. This condition is due to a defect in the gene of dystrophin, which absence causes instability of the membrane and leads to degeneration of muscle fibres.

Regeneration involves the restructuration of the muscular tissue and it requires the participation of extracellular enzymes such as plasmin. The alpha-enolase, an enzyme found in the cytoplasm of cells, enables the activity of plasmin on the cell membrane giving the cell the ability to degrade the surrounding tissue.

In this study, IDIBELL researchers show that the association of alpha-enolase and plasmin regulates two connected processes in the injured muscle or dystrophy: first, the attraction (recruitment) of immune cells to remove damaged tissue and, on the other hand, the formation of new muscle tissue from the stem cells. The researchers observed in the laboratory that these stem cells lost the ability to activate and merge to form skeletal muscle fibers when specific inhibitors of the alfa-enolasa/plasmina union were applied.

The researchers also performed experiments in mice with Duchenne muscular injury. When the animals were treated with the same inhibitors, mice showed a significant defect in muscle regeneration.

"These results demonstrate that the interaction of alpha-enolase and plasmin is necessary for the restoration of damaged muscle tissue", explained Roser Lpez-Alemany, IDIBELL researcher and study coordinator.

Recently, an extensive proteomic meta-analysis identified the alpha-enolase as the first differentially expressed protein in both human pathologies and mouse models, suggesting that "it may be considered a marker of a pathological stress in a large number of diseases", said Lopez-Alemany.

###

This study indicates that the association alfa-enolase/plasmin is a novel selectively target for therapeutic interventions in muscle pathologies because "alpha-enolase is responsible for plasmin activity associated with muscle regeneration", concluded the IDIBELL researcher.

Reference of the paper

Daz-Ramos , Roig-Borrellas A, Garca-Melero A, Llorens A, Lpez-Alemany R. Requirement of Plasminogen Binding to Its Cell-Surface Receptor ?-Enolase for Efficient Regeneration of Normal and Dystrophic Skeletal Muscle. PLoS ONE 7(12): e50477.



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


[ Back to EurekAlert! ] Public release date: 19-Dec-2012
[ | E-mail | Share Share ]

Contact: Ral Toran
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute

The association alfa-enolase/plasmin is a new selectively target for treating muscular pathologies

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) have described a new selective target in muscle regeneration. This is the association of alpha-enolase protein and plasmin. The finding could be used to develop new treatments to regenerate muscular injuries or dystrophies. The study has been published in PLOS ONE journal.

Skeletal muscle has a great regeneration capacity after injury or genetic diseases such as Duchenne muscular dystrophy, the most common neuromuscular disorder in children. This condition is due to a defect in the gene of dystrophin, which absence causes instability of the membrane and leads to degeneration of muscle fibres.

Regeneration involves the restructuration of the muscular tissue and it requires the participation of extracellular enzymes such as plasmin. The alpha-enolase, an enzyme found in the cytoplasm of cells, enables the activity of plasmin on the cell membrane giving the cell the ability to degrade the surrounding tissue.

In this study, IDIBELL researchers show that the association of alpha-enolase and plasmin regulates two connected processes in the injured muscle or dystrophy: first, the attraction (recruitment) of immune cells to remove damaged tissue and, on the other hand, the formation of new muscle tissue from the stem cells. The researchers observed in the laboratory that these stem cells lost the ability to activate and merge to form skeletal muscle fibers when specific inhibitors of the alfa-enolasa/plasmina union were applied.

The researchers also performed experiments in mice with Duchenne muscular injury. When the animals were treated with the same inhibitors, mice showed a significant defect in muscle regeneration.

"These results demonstrate that the interaction of alpha-enolase and plasmin is necessary for the restoration of damaged muscle tissue", explained Roser Lpez-Alemany, IDIBELL researcher and study coordinator.

Recently, an extensive proteomic meta-analysis identified the alpha-enolase as the first differentially expressed protein in both human pathologies and mouse models, suggesting that "it may be considered a marker of a pathological stress in a large number of diseases", said Lopez-Alemany.

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This study indicates that the association alfa-enolase/plasmin is a novel selectively target for therapeutic interventions in muscle pathologies because "alpha-enolase is responsible for plasmin activity associated with muscle regeneration", concluded the IDIBELL researcher.

Reference of the paper

Daz-Ramos , Roig-Borrellas A, Garca-Melero A, Llorens A, Lpez-Alemany R. Requirement of Plasminogen Binding to Its Cell-Surface Receptor ?-Enolase for Efficient Regeneration of Normal and Dystrophic Skeletal Muscle. PLoS ONE 7(12): e50477.



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Source: http://www.eurekalert.org/pub_releases/2012-12/ibri-dak121912.php

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